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The ISO setting is a measure of how sensitive the camera sensor/ film is to light. A low ISO (e.g. 50) is therefore suitable to use in bright situations while a high ISO (e.g. 1600) is best suited to dark conditions (i.e. indoors).
It is always best to use a low ISO where possible as the quality of the photo will be less grainy and clearer. If however you want to acheive a grainy photo, perhaps to add texture or mystique to your image then a high ISO setting will be favoured.
The First image has an ISO on 100 which make the picture quality clearer, the second image has been taken with an ISO of 1600 which has made the photograph grainy.
[...] on my Nikon, I came up with these photos! Here are some links that I think help explain things like ISO, f-stop and aperture well. Understanding what they mean and how to set them on your DSLR is essential for [...]